SGLT2 Inhibitors and Perioperative Period

A

Assiut University

Status

Begins enrollment this month

Conditions

Perioperative Complication

Treatments

Drug: SGLT2 inhibitor

Study type

Observational

Funder types

Other

Identifiers

NCT06326528
SGLT2 inhibitors

Details and patient eligibility

About

The expanded use of SGLT2 inhibitors motivates us to assess the role of SGLT2 inhibitors in perioperative period on patients who will undergo cardiac surgery in Assiut University.

Full description

With over 50 million cases of heart failure worldwide, heart failure is one of the most serious health issues facing humanity. Heart failure patients still have an extremely poor prognosis and quality of life, even with advancements in heart failure treatment. It continues to be the most common cause of hospitalization in elderly. A substantial number of theories have been proposed to explain the beneficial effects of SGLT2 inhibitors. These include blood pressure lowering, increasing diuresis/natriuresis, improving cardiac energy metabolism, preventing inflammation, weight loss, improving glucose control, inhibiting the sympathetic nervous system, preventing adverse cardiac remodeling, preventing ischemia/reperfusion injury, inhibiting the cardiac Na/H exchanger inhibiting SGLT1, reducing hyperuricemia, increasing autophagy and lysosomal degradation, decreasing epicardial fat mass, increasing erythropoietin (EPO) levels, increasing circulating provascular progenitor cells, decreasing oxidative stress; and improving vascular function. In addition to lowering blood sugar, several large trials also have demonstrated cardiovascular and renal benefits in patients with T2DM. Surprisingly, recent data also suggest that SGLT-2 inhibitors may improve cardiovascular and renal outcomes in patients without diabetes, leading to expanded indications for their use.

Enrollment

100 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

1. All subjects with coronary artery disease or valvular heart disease referred to cardiac surgery

Exclusion criteria

  • Congenital heart disease.
  • Cardiomyopathy (EF>40%).
  • Sever renal impairment (eGFR>30).
  • COPD.
  • Marked obesity (BMI<35).
  • Previous cardiac surgery.

Trial design

100 participants in 1 patient group

SGLT2 group
Description:
First group will receive SGLT2 (Dapaglifozin or Empagliflozin) inhibitors one month before surgery and three months after surgery.
Treatment:
Drug: SGLT2 inhibitor

Trial contacts and locations

0

Loading...

Central trial contact

Nader N Fawzy, Master

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location

Resources

© Copyright 2024 Veeva Systems