Shear-wave Elastography Compared to Respiratory Function Testing

Mayo Clinic

Status: Enrolling

Conditions: Respiratory Complication; Respiratory Function Loss

Treatments: Diagnostic Test: Shear-wave elastography

Study type: Interventional

Funder types: Other

Identifiers

NCT04959526

21-003003

Details and patient eligibility

About

The purpose of this study is to evaluate the relationship between transdiaphragmatic pressure (Pdi) and diaphragm shear-wave elastography (SWE) during state-of-the-art respiratory muscle testing including volitional efforts (e.g., maximal inspiratory pressure, maximal expiratory pressure, Valsalva maneuver), as well as maximal phrenic nerve stimulation.

Enrollment: 24 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult male and female healthy volunteers.

Exclusion criteria

• Volunteers who are pregnant.
• Volunteers with known pulmonary pathology (COPD, asthma requiring routine treatment).

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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24 participants in 1 patient group

Respiratory Function Testing

Experimental group

Description:

All subjects will receive standard respiratory function testing and ultrasound-based elastography measurements across various behaviors and conditions

Treatment:

Diagnostic Test: Shear-wave elastography