SHMT1 Polymorphism in Parkinson's Disease,

Assiut University

Status: Unknown

Conditions: Study the Role of SHMT1 Polymorphism in Parkinson Disease

Treatments: Genetic: SHMT1 polymorphism

Study type: Observational

Funder types: Other

Identifiers

NCT04706065

aswan

Details and patient eligibility

About

Parkinson Disease (PD) is the most common movement disorder and represents the second most common degenerative disease of the central nervous system . SHMT has been shown to be associated with various diseases.

Full description

This case -control observational prospective study will conducted on 40 patients with PD.

Enrollment: 80 estimated patients

Sex: All

Ages: 50+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients age ≥ 50 years.
• Patients with PD diagnosed according to the United Kingdom Parkinson's Disease Society Brain Bank (UK PDS Brain Bank diagnostic criteria)

Exclusion criteria

• Patients with parkinsonian plus syndrome

  • Patients with secondary parkinsonism
  • Patients with other chronic comorbidities (renal, hepatic, and endocrinal disturbances and chronic chest disease.)
  • Past and /or present history of epilepsy.
  • Patients with disturbed conscious level.

Trial design

80 participants in 2 patient groups

GROUP 1

Description:

Group 1 (patients with PD) All participants will be subjected to thorough history taking, full clinical and neurological examination. Diagnosis of PD by using Brain Bank Criteria for diagnosis of Parkinson Disease , assessment of the severity of PD by using PDRS and evaluation of cognitive functions using MMSE.

Treatment:

Genetic: SHMT1 polymorphism

Group 2

Description:

Group 2 (controls) All participants will be subjected to thorough history taking, full clinical and neurological examination.

Treatment:

Genetic: SHMT1 polymorphism