Short Atrioventricular Delay Pacing (SAVD)

University of Pittsburgh

Status

Withdrawn

Conditions

Stable Cardiac Status (i.e. no Hospitalizations or Cardiac Medication Changes Within 3 Months)

Chronically (i.e. Implanted for at Least Six Months) Dual-chamber Pacemaker

Treatments

Other: short AVD pacing ; prior (stable) programming

Study type

Interventional

Funder types

Other

Identifiers

NCT01233661

08060137

Details and patient eligibility

About

We intend to examine the effects of temporary elevation of atrial wall stress by shortening of the atrioventricular delay in patients with dual-chamber pacemakers.

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Chronically (i.e. implanted for at least six months) dual-chamber pacemaker
Stable cardiac status (i.e. no hospitalizations or cardiac medication changes within 3 months)
Ability to provide informed consent

Exclusion criteria

Age <18 years or >80 years
Pregnancy (if pregnancy is suspected, a urine pregnancy test will be performed)
Recent (within 12 months) left ventricular ejection fraction <50%
Significant valvular heart disease (mitral regurgitation of greater than mild severity, any degree of mitral stenosis, aortic stenosis or insufficiency of greater than mild severity)
Prior coronary artery bypass graft or valve surgery, recent (i.e. within 3 months) acute coronary syndrome or percutaneous coronary intervention, or chronic stable angina
History of clinically important atrial or ventricular tachyarrhythmias, defined as complex ventricular ectopy (i.e. couplets, triplets, or ventricular tachycardia), AF, atrial tachycardia, or other supraventricular tachycardias not cured with prior ablative therapy).
Significant chronic systemic inflammatory or neoplastic disease
Chronic renal or hepatic insufficiency. Renal insufficiency will be defined as a creatinine clearance of less than 20 cc/min. Evidence of hepatic insufficiency will consist of abnormal synthetic function (INR >1.4 without oral anticoagulant use, albumin < 3.0 mg/dL) or abnormal clearance function (total bilirubin >2.0).
Uncorrected thyroid abnormalities