Short-course Antimicrobial Therapy in Sepsis

Ospedale Santa Maria delle Croci

Status and phase: Unknown; Phase 2

Conditions: Infection; Severe Sepsis; Septic Shock; Sepsis

Treatments: Drug: Antibiotic

Study type: Interventional

Funder types: Other

Identifiers

NCT02899143

1599

Details and patient eligibility

About

The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.

Enrollment: 320 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who received antibiotics for presumed infection

Exclusion criteria

• Prolonged therapy (eg, endocarditis)
• Severe immunosuppression
• Severe infections (due to viruses, parasites, or Mycobacterium tuberculosis)
• Patients previously infected or colonized with multidrug resistant pathogens and moribund patients.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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320 participants in 2 patient groups

Group 5-days

Experimental group

Description:

5-days targeted antibiotic therapy

Treatment:

Drug: Antibiotic

Group 10-days

Other group

Description:

10-days targeted antibiotic therapy

Treatment:

Drug: Antibiotic