King Hussein Cancer Center | Office of Scientific Affairs and Research
Status and phase
Conditions
Treatments
Study type
Funder types
Identifiers
About
The purpose of this study is to show that the addition of COMPOUND 2055269, an immunotherapeutic drug, to Folfox chemotherapy will improve the pathologic complete response rate in patients with locally advanced rectal cancer.
Full description
The purpose of this study is to show that the addition of COMPOUND 2055269, an immunotherapeutic drug, to Folfox chemotherapy will improve the pathologic complete response rate in patients with locally advanced rectal cancer.
COMPOUND 2055269 has demonstrated meaningful clinical activity across various tumor types and treatment settings. No clinical trial is conducted over COMPOUND 2055269 in locally-advanced rectal adenocarcinoma.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Patients aged ≥18 years.
Locally-advanced rectal cancer (cT2 N1-3, cT3 N0-3, evidence of extramural vascular or mesorectal fascia involvement).
<12 cm from anal verge.
Histologically proven rectal adenocarcinoma.
ECOG performance score ≤ 1.
Have adequate organ function by meeting the following:
Negative serum or urine pregnancy test at screening for women of childbearing potential.
Highly effective contraception for both male and female subjects throughout the study and for at least 30 days after last COMPOUND 2055269 treatment administration if the risk of conception exists.
Exclusion criteria
Distant metastasis (M1).
Patients with T2 N0 or T4.
Recurrent rectal cancer.
Symptoms or history of peripheral neuropathy.
Prior radiotherapy or chemotherapy.
Current use of immunosuppressive medication, except for the following:
Active autoimmune disease that might deteriorate when receiving an immunostimulatory agent. Patients with diabetes type I, vitiligo, psoriasis, or hypo- or hyperthyroid diseases not requiring immunosuppressive treatment are eligible.
Vaccination within 4 weeks of the first dose of COMPOUND 2055269 and while on trials is prohibited except for administration of inactivated vaccines.
Active infection requiring systemic therapy.
Known history of testing positive for the human immunodeficiency virus or known acquired immunodeficiency syndrome.
Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection at screening (positive HBV surface antigen or HCV RNA if anti-HCV antibody screening test positive).
Known prior severe hypersensitivity to investigational product or any component in its formulations, including known severe hypersensitivity reactions to monoclonal antibodies (NCI CTCAE v4.03 Grade ≥ 3).
Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (< 6 months prior to enrollment), myocardial infarction (< 6 months prior to enrollment), unstable angina, congestive heart failure (≥ New York Heart Association Classification Class II), or serious cardiac arrhythmia requiring medication.
Persisting toxicity related to prior therapy (NCI CTCAE v. 4.03 Grade > 1); however, alopecia, sensory neuropathy Grade ≤ 2, or other Grade ≤ 2 not constituting a safety risk based on investigator's judgment are acceptable.
Prior organ transplantation including allogenic stem-cell transplantation.
Other severe acute or chronic medical conditions including immune colitis, inflammatory bowel disease, immune pneumonitis, pulmonary fibrosis or psychiatric conditions including recent (within the past year) or active suicidal ideation or behavior; or laboratory abnormalities that may increase the risk associated with study participation or study treatment administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study.
Concurrent treatment with a non-permitted drug.
Patients suspected by the physician that he/she will not compliant to the protocol conduct.
Pregnant or breastfeeding patients.
Patient participating in another clinical trial.
Patient who is not willing to sign the consent form.
Any psychiatric condition that would prohibit the understanding or rendering of informed consent.
Legal incapacity or limited legal capacity patients receiving other oncology specific medication not authorized in the protocol.
Primary purpose
Allocation
Interventional model
Masking
44 participants in 1 patient group
Loading...
Data sourced from clinicaltrials.gov
Clinical trials
Research sites
Resources
Legal