Short Course Radiation Therapy in Palliative Treatment of Thoracic Cancer

Scientific Institute for Research Hospitalization and Healthcare (IRCCS)

Status: Enrolling

Conditions: Radiotherapy; Thoracic Cancer; Palliative Care

Treatments: Radiation: short course treatment; Radiation: standard treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT03804307

RT 15-03 SHARON THORAX

Details and patient eligibility

About

Aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic thoracic malignant lesions

Full description

Standard treatment for thoracic lesions (3000 cGy in 10 daily fractions of 300 cGy each) is compared with experimental treatment (2000 cGy in 4 fractions of 500 cGy twice a day) to demonstrate non-inferiority of this scheme

Enrollment: 72 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• symptomatic thoracic malignant lesions (primary solid tumors or metastases from solid tumor)
• age> 18 years
• Eastern Cooperative Oncology Group (ECOG) Performance Status 0-3
• no changes in supportive care in the week before radiotherapy

Exclusion criteria

• pregnancy
• previous irradiation of the same region

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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72 participants in 2 patient groups

standard treatment

Active Comparator group

Description:

patients in this group are treated with 3000 cGy in 10 daily fraction

Treatment:

Radiation: standard treatment

short course treatment

Experimental group

Description:

patients in this group are treated with 2000 cGy in 4 fractions administered twice a day (at least 6-8 hours interval)

Treatment:

Radiation: short course treatment