Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome (DESAT)

Vaud University Hospital Center

Status and phase

Completed

Phase 4

Conditions

Sleep Apnea Syndromes

Sleep Apnea, Obstructive

Treatments

Drug: Fentanyl and sevoflurane

Drug: Remifentanil and desflurane

Study type

Interventional

Funder types

Other

Identifiers

NCT02717780

CER 192/15

Details and patient eligibility

About

The investigators aim to assess the respiratory effect of short half-life agents in balanced anesthesia on patients suffering from non-treated or suspected obstructive sleep apnea syndrome (OSA) We will study the impact on OSA of a regimen of remifentanil-desflurane versus a regimen of fentanyl-sevoflurane. Each patient will undergo three respiratory portable polygraphies: the night before the surgery ; the first night following the surgery ; the third night following the surgery.

Enrollment

60 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Physical status I - III
Patient scheduled to undergo lower limb orthopedic surgery
Patients known for non-treated obstructive sleep apnea or suspected of having an obstructive sleep apnea

Exclusion criteria

Patients known for treated obstructive sleep apnea ;
Severe respiratory disease (i.e., chronic obstructive pulmonary disease, asthma, pulmonary fibrosis);
Severe cardiovascular disease
Chronic use of opiates ≥ 30mg/j morphine eq.
Chronic use of benzodiazepine
Inability to consent
Refusal