Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous

North Estonia Medical Centre

Status: Unknown

Conditions: Appendicitis Perforated; Acute Appendicitis Without Peritonitis; Appendicitis; Perforation; Acute Appendicitis With Rupture; Acute Appendicitis; Appendicitis Acute; Acute Appendicitis With Appendix Abscess

Treatments: Other: Oral versus intravenous administration of antibacterial treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT04947748

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Details and patient eligibility

About

Short Post-operative Antibacterial Therapy in Complicated Appendicitis: Oral Versus Intravenous is a prospective randomized controlled trial comparing 24 hour intravenous antibacterial therapy to 24 hour oral antibacterial therapy after surgery in complicated appendicitis.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Patients diagnosed with acute appendicitis and are candidates for laparoscopic appendectomy.

Exclusion criteria

Patients with compromised immune system (HIV, diabetes), ongoing or completed radio-chemotherapy in past 5 years, prosthetic heart valve, vascular prosthesis, pregnancy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

24 hour intravenous antibacterial therapy

Active Comparator group

Description:

S.Augmentin 1,2g x 3 i/v

Treatment:

Other: Oral versus intravenous administration of antibacterial treatment

24 hour oral antibacterial therapy

Experimental group

Description:

T.Augmentin 1g x 3 p/o

Treatment:

Other: Oral versus intravenous administration of antibacterial treatment