Short-Term Androgen Priming Before COS Using Aromatase Inhibitor and hCG During Early-Follicular-Phase GnRH Antagonist Administration - a Randomized Controlled Trial

Rigshospitalet

Status and phase: Completed; Phase 4

Conditions: Infertility

Treatments: Drug: Downregulation and androgen priming by use of GnRH antagonist, aromatase inhibitor and hCG before COH

Study type: Interventional

Funder types: Other

Identifiers

NCT00286364

version 01.2005-05-20

Details and patient eligibility

About

We want to investigate if early follicular phase downregulation and androgen priming, by use of GnRH antagonist, aromatase inhibitor and hCG before COH in a short protocol, shows signs of improvement compared to standard short antagonist protocol

Sex: Female

Ages: 18 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Indication and wish for IVF/ICSI treatment
• Womens age 20-39 years (both inclusive)
• Regular menstrual cycle within normal range
• Body Mass Index: 18-30 kg/m2 (both inclusive)
• Negative pregnancy test before treatment
• A maximum of 3 earlier IVF/ICSI treatments that did not result in pregnancy

Exclusion criteria

• serious systemic disease
• Presence of polycystic ovarian syndrome (PCOS)
• Earlier poor response with less than 4 mature follicles
• Earlier participation in the investigation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)