Short-Term Anti-plaque Effect of Cymenol Mouthwash Analysed Using Dentius Deep Plaque Software

University of Santiago de Compostela

Status and phase: Completed; Phase 1

Conditions: Dental Plaque; Healthy

Treatments: Drug: Cymenol mouthwash; Drug: Placebo Mouthwash

Study type: Interventional

Funder types: Other

Identifiers

NCT05521230

2021_CE112

Details and patient eligibility

About

The objective of this project was to investigate the short-term in situ anti-plaque effect of cymenol, using the Dentius Deep Plaque software

Enrollment: 60 patients

Sex: All

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria were as follows:

• Systemically healthy volunteers
• Age between 20-45 years
• Presence of minimum of 24 permanent teeth
• No evidence of gingivitis or periodontitis (CPITN= 0)
• No presence of untreated caries at the start of the study.

Exclusion criteria were as follows:

• Smoker or ex-smoker
• Presence of dentures or orthodontic appliances
• Antibiotic treatment in the last 3 months or routine use of oral antiseptics

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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60 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

Participants rinsed 10 ml of placebo mouthwash for a period of 60 seconds, three times a day with an interval of 7-9 hours in between, for 4 days (period 1)

Treatment:

Drug: Placebo Mouthwash

Cymenol (test)

Experimental group

Description:

Participants applied a 10 ml rinse of 0.1% cymenol mouthwash for a period of 60 seconds, three times a day with a 7-9 hour interval in between, for 4 days (period 1) and 4 days more (period 2)

Treatment:

Drug: Cymenol mouthwash