Short-term Cardiovascular Benefits of Wearing Particulate-filtering Respirators

Fudan University

Status: Completed

Conditions: Inflammation; Autonomic Nervous System Imbalance; Vasoconstriction; Blood Coagulation Disorders; Blood Pressure

Treatments: Behavioral: Wear respirator

Study type: Interventional

Funder types: Other

Identifiers

NCT02238028

KZGY 001

Details and patient eligibility

About

An intervention study to assess the short-term cardiovascular effects of reducing personal air pollution exposure by wearing particulate filtering respirators.

Full description

A group of healthy adult college students fulfilling the recruitment criteria were randomly divided into two sub-groups. One sub-group weared the particulate filtering respirators for 2 continuous days during which the respirator was required to wear as much as possible both indoor and outdoor. The other group acted as normal at the same time. The measurements on health effects including heart rate varibility, blood pressure, circulating biomarkers as well as the ambient air pollution were performed in both groups during the intervention period. After a 3-week rest period,the two groups interchanged their roles of wearing the respirator or not. The same measurements of both health effects indicators and ambient air pollution were repeated.

Enrollment: 28 patients

Sex: All

Ages: 18 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Equal to or older than 18 years old,
• No history of smoking and alcohol addiction.
• No chronic diseases,such as hypertension,diabetes,chronic obstructive pulmonary disease or other respiratory/cardiovascular diseases reported by volunteers.
• No respiratory or allergic diseases, like asthma, rhinitis,or other allergic diseases.

Exclusion criteria

• Current smokers
• Chronic drug use due on cardiovascular or respiratory diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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28 participants in 2 patient groups

Wear respirator

Experimental group

Description:

The recruited healthy subjects were randomly allocated into two groups.In each intervention, one group wore the high-efficiency respirator as much as possible for continuous 48hr and the other group behaved as usual. After a three-week interval, the two groups exchanged their roles in wearing the respirator or not. The same protocol on the measurements of health indicators and ambient air pollution was applied in the 1st intervention and 2nd intervention period.

Treatment:

Behavioral: Wear respirator

Not wear respirator

No Intervention group

Description:

The recruited healthy subjects were randomly allocated into two groups.In each intervention, one group wore the high-efficiency respirator as much as possible for continuous 48hr and the other group behaved as usual. After a three-week interval, the two groups exchanged their roles in wearing the respirator or not. The same protocol on the measurements of health indicators and ambient air pollution was applied in the 1st intervention and 2nd intervention period.