Short-term Effect of Glucose and Sacharose Ingestion on Cognitive Performance and Mood in Elderly

Wageningen University

Status: Completed

Conditions: Cognition; Attention; Memory; Mental Health

Treatments: Dietary Supplement: sacharose; Dietary Supplement: Placebo; Dietary Supplement: glucose

Study type: Interventional

Funder types: Other

Identifiers

NCT01427231

NL36813.081.11

Details and patient eligibility

About

The objective of the current study is to determine the acute effect of a glucose drink and a sacharose drink compared to a placebo on cognitive performance in elderly with light memory complaints. The investigators expect that the sugar containing drinks will improve memory and attentional functions. Furthermore, blood glucose response will be measured.

Enrollment: 43 patients

Sex: All

Ages: 70+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Men and women
• 70 years and older
• Memory complaints

Exclusion criteria

• Type I or II diabetes
• Parkinson disease
• MMSE < 25 (to exclude cognitively impaired subjects
• CES-D > 16 (to exclude depressive subjects)
• Pharmacological antidepressives or medication for dementia
• Liver disease

Trial design

43 participants in 3 patient groups, including a placebo group

Drink with 50 g glucose

Active Comparator group

Description:

The glucose drink contains 50 g of glucose soluted in 250 ml of water and lemon juice.

Treatment:

Dietary Supplement: glucose

Drink with 100 gram of sacharose

Active Comparator group

Description:

The sacharose drink contains 100 g of sacharose soluted in 250 ml of water and lemon juice.

Treatment:

Dietary Supplement: sacharose

Placebo with sweeteners

Placebo Comparator group

Description:

The placebo contains a mixture of artificial sweeteners in order to have the same sweetness and appearance of the test drinks (the glucose drink and the sacharose drink).

Treatment:

Dietary Supplement: Placebo