Short-term Effect of Rho-kinase Inhibitor on Retinal Circulation

University of the Incarnate Word

Status and phase: Unknown; Early Phase 1

Conditions: Glaucoma, Open-Angle

Treatments: Drug: Netarsudil Ophthalmic

Study type: Interventional

Funder types: Other

Identifiers

NCT04234932

19-12-005

Details and patient eligibility

About

Investigate changes in optical coherence tomography angiography of the optic nerve and macula following topical instillation of commercial preparations of netarsudil 0.02% ophthalmic solution.

Enrollment: 10 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Normal ocular health

Exclusion criteria

• Females who are or may be pregnant or who are nursing
• Uncontrolled hypertension
• Allergy to netarsudil or latanoprost

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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10 participants in 2 patient groups

Netarsudil alone

Experimental group

Description:

Topical application of netarsudil 0.02%

Treatment:

Drug: Netarsudil Ophthalmic

Netarsudil plus latanoprost

Active Comparator group

Description:

Topical application of netarsudil 0.02% with latanoprost 0.005%

Treatment:

Drug: Netarsudil Ophthalmic