Short-term Effects of Broccoli-derived Glucoraphanin on Recovery From Eccentric Muscle Damage

Lithuanian Sports University

Status

Begins enrollment this month

Conditions

Healthy

Treatments

Dietary Supplement: Placebo (no broccoli-derived bioactives)

Dietary Supplement: broccoli powder consumption

Study type

Interventional

Funder types

Other

Identifiers

NCT07373106

MNLKIN(M)-2024-574

Details and patient eligibility

About

Eccentric exercise induces muscle damage and delay functional recovery. Broccoli-derived glucoraphanin (a sulforaphane precursor that activates Nrf2 defenses) may aid repair; however, its short-term effects in humans remains unknown. This study aims to evaluate whether short-term supplementation with broccoli-derived glucoraphanin will improve recovery from exercise-induced muscle damage. In a randomized, double-blind, placebo-controlled crossover design, fifteen participants will consume either high-glucoraphanin broccoli powder (320 μg) or placebo for one week, followed by elbow flexor eccentric exercise and continued supplementation. Strength, soreness, creatine kinase (CK), range of motion (ROM), arm girths, and ultrasound-assessed muscle and tendon morphology will be measured at baseline, immediately post-exercise, and at 48 and 96 hours post-exercise.

Enrollment

17 estimated patients

Sex

Male

Ages

18 to 35 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

no resistance training experience in the past 6 months, no arm injuries in the past 2 years, no illnesses in the month prior to data collection, and no known allergies to broccoli or other cruciferous vegetables.

Exclusion criteria