Short-term Effects of Oxytocin Nasal Spray on Chronic Tinnitus

Berthold Langguth, MD, Ph.D.

Status: Completed

Conditions: Chronic Tinnitus

Treatments: Drug: Placebo; Drug: Syntocinon

Study type: Interventional

Funder types: Other

Identifiers

NCT02508220

Uni-Reg-Oxy-Tin

Details and patient eligibility

About

The study compares the short-term tinnitus reduction following a single oxytocin intervention with a placebo control condition.

Enrollment: 15 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• chronic tinnitus with a duration > 6 months
• medical examination by an ENT specialist
• sufficient knowledge of the Portuguese language to follow the instructions and answer the questionnaires
• VAS score >4 points

Exclusion criteria

• vascular tinnitus
• muscular tinnitus
• conductive hearing loss
• previous experience with oxytocin nasal spray
• additional medications during the intervention

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Quadruple Blind

---

15 participants in 2 patient groups

Oxy-Placebo

Other group

Description:

Syntocinon first, Placebo second 2 puffs in each nostril

Treatment:

Drug: Syntocinon

Drug: Placebo

Placebo-Oxy

Other group

Description:

Placebo first, Syntocinon second 2 puffs in each nostril

Treatment:

Drug: Syntocinon

Drug: Placebo