Short Term Effects of Photodynamic Therapy in Basal Cell Carcinoma

Shahid Beheshti University of Medical Sciences

Status and phase: Completed; Phase 1

Conditions: Basal Cell Carcinoma

Treatments: Radiation: photodynamic therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT01015898

pdt1

NCT00985830 (Other Grant/Funding Number)

Details and patient eligibility

About

The purpose of this study is to evaluate the efficacy of photodynamic therapy in treatment of Basal cell carcinoma (BCC) and factors that affect response rate.

Full description

Background and Aim: Basal cell carcinoma (BCC) is the most common skin cancer .Photodynamic therapy _as a novel , non-invasive therapeutic approach _may be considered a valuable strategy. This study was designed with the aim of the evaluation of efficacy of PDT in treatment of BCC and factors that may affect response rate.

Materials and Methods: This was a clinical trial which was done on 28 BCCs. Patients were treated with ALA-PDT monthly for 1-6 sessions and evaluated for clinical response,cosmetic results and probable side effects.

Enrollment: 28 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Histologically proven BCCs

Exclusion criteria

• Rodent ulcer
• Morphea type
• ANA +
• History of photosensitivity or photodermatosis or ingestion of phototoxic
• Drugs during last month
• Pregnancy
• Breast feeding
• Age< 18
• History of another therapeutic intervention for bcc during last 6 months

Trial design

Primary purpose: Treatment

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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28 participants in 1 patient group

BCC, ALA-PDT

Experimental group

Description:

Patients with histologically proven basal cell carcinoma who were candidates for treatment with ALA-PDT

Treatment:

Radiation: photodynamic therapy