Short-term Health Benefits of Using Fresh Air Filtration System in Classroom

Fudan University

Status: Completed

Conditions: Cognitive and Attention Disorders and Disturbances; Oxidative Stress; Airway Morbidity

Treatments: Device: Fresh air system with filtration

Study type: Interventional

Funder types: Other

Identifiers

NCT03788330

XFGY001

Details and patient eligibility

About

A randomized crossover trial will be conducted in 90 primary school children in 3 classrooms in Shanghai, China. The effects of fresh air ventilation/filtration system, fresh air ventilation system with no filtration and natual ventilation will be compared on the effects of reducing indoor PM2.5 and chilhood health. Biological samples of children are going to be collected to investigate the associations between indoor air pollution and biomarkes of certain health effects.

Full description

A randomized crossover trial among 90 primary students in 3 classrooms in Shanghai, China will be performed. Three arms are going to be 1) fresh air filtration system, 2) fresh air system with no filtration and 3) natural ventilation. Each arm is going to be in use for five continuous weekdays followed by one week of wash-out. After one-week of wash out, a cross over change between 3 arms is going to be taked. Then the 2nd week of intervention is performed followed by the 2nd wash-out week. The same cross-over change between 3 arms is going to be repeated again until each classroom will be applied by all three arms of ventilation. A total of 5 weeks is required for the project. Children's biological samples including saliva, urine and skin samples will be collected as well as exhaled NO. A questionnaire on children's perception on air quality will be assessed as well.

Enrollment: 94 patients

Sex: All

Ages: 10 to 13 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• All invited primary school children in Grade 5 in an artibrarily selected school

Exclusion criteria

• Current airway symptoms (cough, airway infection, asthma et al.)
• Acute infectious diseases

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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94 participants in 3 patient groups, including a placebo group

Fresh air system with filtration

Experimental group

Description:

A fresh air ventilation system combined with PM2.5 filtration is applied in one primary school classroom.

Treatment:

Device: Fresh air system with filtration

Fresh air system with no filtration

Placebo Comparator group

Description:

A fresh air ventilation system with no PM2.5 filtration is applied in a parallel classroom.

Treatment:

Device: Fresh air system with filtration

Natural ventilation

No Intervention group

Description:

Natural ventilation system was applied in the 3rd classroom as normal.