Short-term Regulation of Energy and Macronutrient Balance: Impact of Energy Flux (EF)

University of Hohenheim

Status: Completed

Conditions: Healthy

Treatments: Behavioral: physical activity; Behavioral: energy intake

Study type: Interventional

Funder types: Other

Identifiers

NCT03361566

EF2016

Details and patient eligibility

About

Aim of the study is to investigate the impact of energy flux (achieved by changes in physical activity) under the conditions of energy balance, caloric restriction and overfeeding in healthy subjects.

Full description

A low energy flux is achieved by low energy expenditure, equivalent to low physical activity and with a corresponding low energy intake. A high energy flux is achieved by high energy expenditure, equivalent to high physical activity and with a corresponding high energy intake, respectively.

The protocol of this randomized, intra-individual nutrition intervention includes 12 one-day interventions with 3 different levels of energy flux and 4 different diet conditions.

Enrollment: 16 patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 20-40 years of age
• healthy
• BMI between 18.5 and 31 kg/m2

Exclusion criteria

• smoking
• food allergies
• alternative nutrition habits like vegetarian / vegan
• chronic diseases
• regular medication intake
• claustrophobia
• weight loss > 5 kg in the last 3 years

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 12 patient groups

low energy flux at ad libitum energy intake

Experimental group

Description:

physical activity: inactive energy intake: ad libitum

Treatment:

Behavioral: physical activity

Behavioral: energy intake

medium energy flux at ad libitum energy intake

Experimental group

Description:

physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: ad libitum

Treatment:

Behavioral: physical activity

Behavioral: energy intake

high energy flux at ad libitum energy intake

Experimental group

Description:

physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: ad libitum

Treatment:

Behavioral: physical activity

Behavioral: energy intake

Low energy flux at energy balance

Experimental group

Description:

physical activity: inactive energy intake: individual energy balance

Treatment:

Behavioral: physical activity

Behavioral: energy intake

medium energy flux at energy balance

Experimental group

Description:

physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: individual energy balance

Treatment:

Behavioral: physical activity

Behavioral: energy intake

high energy flux at energy balance

Experimental group

Description:

physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: individual energy balance

Treatment:

Behavioral: physical activity

Behavioral: energy intake

low energy flux at caloric restriction

Experimental group

Description:

physical activity: inactive energy intake: caloric restriction -25%

Treatment:

Behavioral: physical activity

Behavioral: energy intake

medium energy flux at caloric restriction

Experimental group

Description:

physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: caloric restriction -25%

Treatment:

Behavioral: physical activity

Behavioral: energy intake

high energy flux at caloric restriction

Experimental group

Description:

physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: caloric restriction -25%

Treatment:

Behavioral: physical activity

Behavioral: energy intake

low energy flux at overfeeding

Experimental group

Description:

physical activity: inactive energy intake: overfeeding +25%

Treatment:

Behavioral: physical activity

Behavioral: energy intake

medium energy flux at overfeeding

Experimental group

Description:

physical activity: medium (3 x 55 min treadmill running at 4 km/h) energy intake: overfeeding +25%

Treatment:

Behavioral: physical activity

Behavioral: energy intake

high energy flux at overfeeding

Experimental group

Description:

physical activity: high (3 x 110 min treadmill running at 4 km/h) energy intake: overfeeding +25%

Treatment:

Behavioral: physical activity

Behavioral: energy intake