SHR-A1921 Combined With Bevacizumab in Triple-negative Breast Cancer With Brain Metastases

Fudan University logo

Fudan University

Status and phase

Not yet enrolling
Phase 2


Brain Metastasis


Drug: SHR-A1921 + Bevacizumab

Study type


Funder types




Details and patient eligibility


This is a phaseⅡ, single-arm study evaluating the efficacy and safety of SHR-A1921 Combined with Bevacizumab in Triple-negative Breast Cancer with Brain Metastases


24 estimated patients




18+ years old


No Healthy Volunteers

Inclusion criteria

  1. Age ≥ 18 years old, both genders

  2. ECOG Performance Status of 0-2

  3. Pathological tests confirm HR-negative/HER2-negative breast cancer;there is evidence of local recurrence or metastasis;not suitable with curative surgery or radiation therapy;HR negative is defined as: ER-negative and PR-negative, the proportion of positively stained tumor cells in all tumor cells is <10%;HER2- negative is defined as: histologically confirmed to be HER2 IHC (0) or HER2 IHC(1+) or HER2 IHC (2+) and FISH(-)

  4. Must have life-expectancy of ≥ 3 months

  5. MRI confirmed brain metastases, at least one intracranial parenchymal metastatic lesion with a longest diameter ≥ 1.0 cm without prior radiotherapy;

  6. Intraventricular catheter shunting or mannitol、steroid hormone、anticonvulsant drug is allowed before enrollment, but the dose of drug should be stable for at least one week and the neurological symptoms are stable for ≥1 week

  7. Adequate function of major organs meets the following requirements (1)Blood routine

    • ANC≥1.5×109/L;
    • PLT≥75×109/L;
    • Hb≥90 g/L(Allows blood transfusion or the use of medication to ensure that the content of hemoglobin) (2)Coagulation
    • INR≤1.5,APTT≤1.5×ULN (3)Blood biochemistry
    • TBIL≤1.5 × ULN;
    • ALT and AST≤3 × ULN (liver metastasis≤5.0 × ULN);
    • Urea nitrogen ≤ 1.5 × ULN; Cr≤1.5 × ULN or creatinine clearance ≥50 mL / min (Cockcroft-Gault formula) (4)Cardiac ultrasound
    • LVEF≥50%; (5)12-lead ECG:
    • females QTcF interval <470msec and males <450ms;
  8. Willing to join the study, sign informed consent, have good compliance and cooperate with follow-up.

Exclusion criteria

  1. Leptomeningeal or cystic metastases confirmed by MRI or lumbar puncture
  2. Presence of third interstitial fluid that cannot be controlled by drainage or other methods (e.g., a large amount of pleural effusion and ascites);
  3. Whole brain radiotherapy, chemotherapy, biological targeted therapy, immunotherapy, surgery or endocrine therapy within 2 weeks prior to enrolment
  4. Has received prior therapy with bevacizumab and TROP-2 ADC drugs
  5. Participation in any other clinical trials within 2 weeks of enrollment
  6. Concurrent use of any other Anti-cancer drugs
  7. Other malignancies within 5 years, except cured in-situ of uterine cervix carcinoma , skin basal cell carcinoma and squamous-cell carcinoma
  8. History of heart disease: (1) Arrhythmias requiring medical treatment or clinical significance, (2) Myocardial infarction, (3) Heart failure, (4)Any heart diseases that investigator believes not suitable for this study
  9. History of allergy or hypersensitivity to any of the study drugs or study drug components
  10. History of immunodeficiency including HIV-positive, active hepatitis B/C, other acquired, congenital immunodeficiency disease or history of organ transplantation
  11. A clear history of neurological or mental disorders, including epilepsy or dementia
  12. Pregnant or breastfeeding women. Women of childbearing potential who have a positive pregnancy test or unwilling to use adequate contraception prior to enrollment and for the duration of study participation
  13. According to the investigator's judgment, there is a concomitant disease that seriously endangers the safety of subjects or affects the completion of the study (including but not limited to severe hypertension, severe diabetes, active infection, thyroid disease that cannot be controlled by drugs)
  14. Any condition which in the investigator's opinion makes the subjects unsuitable for the study participation

Trial design

Primary purpose




Interventional model

Single Group Assignment


None (Open label)

24 participants in 1 patient group

SHR-A1921 + Bevacizumab
Experimental group
Drug: SHR-A1921 + Bevacizumab

Trial contacts and locations



Central trial contact

Biyun Wang

Data sourced from

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems