Shrunken Pore Syndrome: a Retrospective, Single Center, Cohort Study

Henrik Bjursten

Status: Completed

Conditions: Kidney Diseases

Treatments: Diagnostic Test: Shrunken Pore Syndrome

Study type: Observational

Funder types: Other

Identifiers

NCT04141072

SPS (Other Identifier)

Details and patient eligibility

About

To study the impact a difference in renal clearance of small and large molecules has on long-term survival.

Full description

Renal dysfunction is considered a major risk factor in cardiac surgery. Renal function has earlier been estimated by creatinine and more recently by cystatin C, both of which are analysed in a blood sample. New evidence seems to suggest that if the ratio between estimated renal function from cystatin C and creatinine is below 60% the patient has a higher rate of mortality irrespective of renal function. This syndrome is named Shrunken Pore Syndrome.

We study patients whom have undergone elective cardiac surgery at our institution and on whom we before the surgery has collected blood samples. They are all included in our in house patient registry and qulaity database and afterwards we match this data to our national tax registry to get data on mortality.

Our aim is to evaluate whether Shrunken Pore Syndrome influence mortality following elective cardiac surgery.

Enrollment: 4,719 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Elective CABG and/or sAVR at the department of Cardiothoracic Surgery, Skåne University Hospital in Lund, Sweden between 1 January 2010 and 31 December 2015.

Exclusion criteria

• Emergency operation
• Redo operation
• Preoperatively missing cystatin C or creatinine