SIBO & SIFO After Colectomy

Augusta University

Status: Completed

Conditions: Small Intestinal Fungal Overgrowth; Colectomy; Small Intestinal Bacterial Overgrowth

Study type: Observational

Funder types: Other

Identifiers

NCT03216239

659642

Details and patient eligibility

About

After subtotal colectomy, 40% of patients report abdominal pain, gas and diarrhea, and poor quality of life; whose etiology is unknown. The investigators determined whether small intestinal bacterial (SIBO or fungal overgrowth SIFO) could cause these sympotoms (> 1 year).

Enrollment: 100 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

patients who were referred to a specialist motility center over 4 year period with:

• Unexplained gastrointestinal symptoms such as gas, bloating, belching, diarrhea, and abdominal discomfort
• history of colectomy
• patients with no history of colectomy
• patients included who had normal: upper endoscopy, colonoscopy, computerized abdominal tomography scan, and normal hematology, biochemical profiles, tissue transglutaminase antibody, thyroid stimulating hormone, and normal right upper quadrant ultrasound scan.
• patients with glucose breath test and/or duodenal aspirate

Exclusion criteria

• patients with upper gut or small bowel surgery
• Patients who were hospitalized or with serious cardiac or pulmonary or neurologic comorbidities
• Patients with intestinal strictures or known intestinal motility disorders such as scleroderma or pseudo-obstruction syndrome

Trial design

100 participants in 2 patient groups

Colectomy Group

Description:

Mean age 52.3 years (range:20-85), 82% females, and a mean duration of symptoms of 79.9 months in the colectomy group. The indication for colectomy was constipation (36%), diverticular disease (8%), bowel obstruction (8%), colorectal carcinoma (8%), colon polyps (6%), and other (34%).

Control Group

Description:

Mean age of 49.9 years (range 18-88), 76% females, and mean duration of symptoms 77.6 months,