Sidestream Dark-Field (SDF) Imaging of the Intestinal Microcirculation

Nova Scotia Health Authority (NSHA)

Status: Completed

Conditions: Sepsis

Study type: Observational

Funder types: Other

Identifiers

NCT00883597

CDHA-RS/2009-311

Details and patient eligibility

About

Sepsis is the most frequent cause of death in critically ill patients in non-coronary care Intensive Care Units in the developed world. Microcirculatory disturbances are central to the development of the disorder, leading to organ dysfunction, multi-organ failure and fatal outcome.

In particular the intestinal microcirculation is impaired early in the course of the disease. This may result in a breakdown of the gut barrier function with translocation of bacteria and their toxins into the systemic circulation, thus sustaining a "gut derived" septic state. Therefore, the impaired intestinal microcirculation has been suggested to act as the "motor of multiple organ failure" in sepsis.

The aim of the project is to evaluate a new diagnostic tool and the impact of Activated Protein C administration on the intestinal microcirculation in patients with severe sepsis and compare the findings with septic patients who are not candidates for APC therapy and healthy patients post bowel surgery using an innovative diagnostic tool (side stream dark-field imaging, SDF).

Enrollment: 36 patients

Sex: All

Ages: 19+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ileostomy, no infection at the site of stoma, informed consent.
• diagnosed sepsis according to American College of Chest Physicians/Society of Critical Care Medicine criteria13.
• indication for treatment according to hospital guidelines

Exclusion criteria

• infection at the site of stoma,
• moribund patients

Trial design

36 participants in 2 patient groups

Controls

Description:

Patients with ileostomy.

Standard Sepsis Treatment

Description:

Patients with ileostomy and sepsis