Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma

Sohag University

Status: Completed

Conditions: Renal Cell Carcinoma

Treatments: Diagnostic Test: sectioning and staining of renal neoplasms after nephrectomy operation

Study type: Observational

Funder types: Other

Identifiers

NCT04873180

Soh-Med-21-04-28

Details and patient eligibility

About

detection of Survivin expression in renal cell carcinoma and correlate this expression to tumor grade and stage.

Full description

renal cell carcinoma is the third most prevalent malignant tumor of the genitourinary system. deregulation of apoptosis is involved in carcinogenesis by abnormally prolonged cell survival, facilitating accumulations of multiple mutations and augment resistance to immune-surveillance. Survivin is a member of inhibitor of Apoptosis Protein family (IAPs). it play a role in cell cycle regulation by inhibiting apiptosis. Survivin is over-expressed in many human neoplasms.

Enrollment: 40 patients

Sex: All

Ages: 30 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients suffer from renal cell carcinomas

Exclusion criteria

• patients received pre-operative chemotherapy or radiotherapy. patients with insufficient clinical data.