Significance of Synbiotics on Inflammation and Proliferation of Colonic Mucosa

Region Skane

Status: Completed

Conditions: Inflammation

Treatments: Dietary Supplement: Lactobacillus; Dietary Supplement: Bifidobacterium

Study type: Interventional

Funder types: Other

Identifiers

NCT01534572

538/2005

Details and patient eligibility

About

There is a constant exchange between the gut epithelium and lumen, including microbial interplay. The aim of this study was to investigate dietary test products on inflammatory proliferation markers in the gut, and thereby if the products had positive effects in the gut as well as in other parts of the body.

The hypothesis was that the test products would reduce the inflammatory and proliferation activity of the gut epithelium by fermentation of normal food products and by converting dietary phenolic compounds into anti-inflammatory substances.

Enrollment: 12 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 18-80 years old,
• Able to understand oral and written information,
• Informed consent

Exclusion criteria

• Ongoing immune suppressive treatment, incl. cortisone,
• Ongoing antibiotic treatment or antibiotic treatment ended within 4 weeks,
• History of inflammatory bowel disease

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

---

12 participants in 2 patient groups

Probiotics_Lactobacillus

Experimental group

Description:

Intervention (2 weeks) with a strain of Lactobacillus

Treatment:

Dietary Supplement: Lactobacillus

Probiotics_Bifidobacterium

Experimental group

Description:

Intervention (2 weeks) of daily supplementation of a probiotic strain of Bifidobacterium.

Treatment:

Dietary Supplement: Bifidobacterium