Sildenafil Citrate in Frozen Embryo Transfer

Omar Ahmed El Sayed Saad

Status and phase: Completed; Phase 2

Conditions: Infertility

Treatments: Drug: estradiol valerate; Drug: Sildenafil citrate

Study type: Interventional

Funder types: Other

Identifiers

NCT02845388

Ainshams2015Omar

Details and patient eligibility

About

Comparison between usage of Sildenafil citrate with estradiol valerate or estradiol valerate alone in endometrial preparation and outcome of frozen-thawed embryo transfer cycles.

Enrollment: 90 patients

Sex: Female

Ages: 20 to 37 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• all cases have at least 2 good quality blastocysts available for transfer

Exclusion criteria

• uterine structural abnormalities
• advanced uterine disease
• hydrosalpinx and pyosalpinx

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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90 participants in 2 patient groups

estradiol valerate

Active Comparator group

Description:

estradiol valerate 2mg every 12 hours orally starting from the second day of the menstrual cycle till reaching trilaminar endometrial pattern and endometrial thickness 8 mm or more

Treatment:

Drug: estradiol valerate

Sildenafil citrate and estradiol valerate

Active Comparator group

Description:

Sildenafil citrate 25 mg every 6 hours orally in combination with estradiol valerate 2mg every 12 hours orally starting from the second day of the menstrual cycle till reaching trilaminar endometrial pattern and endometrial thickness 8 mm or more

Treatment:

Drug: Sildenafil citrate

Drug: estradiol valerate