Sildenafil Citrate of in Vitro Fertilization After Multiple IVF Failures Attributed to Poor Endometrial Development

Ain Shams University

Status and phase: Unknown; Phase 4

Conditions: IVF Failure

Treatments: Drug: matching placebo; Drug: Sildenafil Citrate

Study type: Interventional

Funder types: Other

Identifiers

NCT03044561

amr el-sayed 2017

Details and patient eligibility

About

The aim of this study is to evaluate the effect of sildenafil citrate on endometrial development in women with history of recurrent implantation failure after IVF

Full description

sildenafil citrate may increase endometrial thickness in women with recurrent IVF failure attributed to poor endometrial development

Enrollment: 80 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• (1) cases of infertility, older than 20 years of age and not older than 40 years.
• (2) Body mass index (BMI):20-29.
• (3) women have experienced two or more implantation failure attributed to inadequate endometrial development.

Exclusion criteria

• (1) Uterine abnormalities (e.g. septate, bicornuate and fibroid uterus, Asherman Syndrome).

• (2) Any contraindication to sildenafil citrate or any of the components of its formulation including:

  • Concurrent use of organic nitrites and nitrates.
  • Severe hepatic impairment.
  • Severe renal impairment.
  • Hypotension.
  • Recent stroke or heart attack.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups, including a placebo group

Sildenafil citrate

Experimental group

Treatment:

Drug: Sildenafil Citrate

placebo

Placebo Comparator group

Treatment:

Drug: matching placebo