Silent Breast Cancer A Study of the Disease Prevalence Held by Imaging Guided Biopsies in Autopsy Specimens (SISYPHUS)

Centro Hospitalar Lisboa Ocidental

Status: Unknown

Conditions: Male Breast Cancer; Female Breast Cancer

Treatments: Other: Biopsy; Procedure: Bilateral mastectomy

Study type: Interventional

Funder types: Other

Identifiers

NCT02480933

CentroHLO

Details and patient eligibility

About

The aim of this study is to define silent breast cancer prevalence in both sexes and will be held by biopsies performed in imaging suspicious areas of the breast (ecography and mammography) in cadavers without known breast cancer.

Full description

Cadavers of both sexes are going to be submitted to bilateral mastectomy. The specimens are going to be examined by palpation, ecography and mammography and all areas with (Breast Imaging Reporting and Data System) BI-RADS classification >= 3 are going to be biopsied.

Biopsy specimens are going to be processed by the pathology department and cancers are going to be identified and classified by their molecular type.

The investigators intend to know which is the disease reservoir in various ages.

Enrollment: 768 estimated patients

Sex: All

Ages: 40+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Female and male cadavers above 40 years

Exclusion criteria

• Known breast cancer
• Breast tissue accidental damage

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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768 participants in 2 patient groups

female cadavers

Experimental group

Description:

female cadavers above 40 years without known breast cancer Bilateral mastectomy Biopsy

Treatment:

Procedure: Bilateral mastectomy

Other: Biopsy

Male cadavers

Experimental group

Description:

male cadavers above 40 years without known breast cancer Bilateral mastectomy Biopsy

Treatment:

Procedure: Bilateral mastectomy

Other: Biopsy