Silver Diamine Flouride in Arresting Enamel Caries

HITEC-Institute of Medical Sciences

Status: Completed

Conditions: Carious Lesion

Treatments: Drug: 38% Silver Diamine Fluoride

Study type: Interventional

Funder types: Other

Identifiers

NCT07125937

Dr Kinza

Details and patient eligibility

About

This interventional study aims to evaluate the effectiveness of 38% Silver Diamine Fluoride (SDF) in arresting enamel caries in adults aged 18-50 years. Dental caries is a biofilm-mediated, multifactorial disease that can cause progressive tooth damage. Conventional treatments are invasive and costly, whereas SDF offers a non-invasive, low-cost alternative. A total of 250 patients meeting the inclusion criteria will be treated with SDF following the UCSF protocol. Lesions will be evaluated clinically using ICDAS and radiographically using ICCMS at 3 weeks and 3 months post-intervention. The primary outcome is the proportion of enamel caries lesions arrested after treatment. Data will be analyzed using the chi-square test.

Enrollment: 250 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age group of subjects between 18 - 50 years

Carious lesions with ICDAS score 1, 2 and 3 in molars and premolars

Exclusion criteria

• PDL widening with periapical radiolucency around molars and premolars

Premolars and Molars with any white lesions other than caries

Third molars

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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250 participants in 1 patient group

38% Silver Diamine Fluoride Application

Experimental group

Description:

Participants will receive a single application of 38% Silver Diamine Fluoride (Advantage Arrest™, Elevate Oral Care LLC) on enamel caries lesions (ICDAS scores 1-3) in molars and premolars, following the UCSF protocol. Lesions will be evaluated clinically (ICDAS) and radiographically (ICCMS) at 3 weeks and 3 months post-treatment to assess caries arrest.

Treatment:

Drug: 38% Silver Diamine Fluoride