Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers

The University of Hong Kong (HKU)

Status: Unknown

Conditions: Dental Caries; Dental Caries of Root Surface

Treatments: Drug: Distilled Water; Drug: Silver Diamine Fluoride

Study type: Interventional

Funder types: Other

Identifiers

NCT03185104

SDF RPD wearers

Details and patient eligibility

About

This study measures and compares the effect of silver diamine fluoride (SDF) on caries increment in removable partial denture wearers. Half of the participants will SDF and while the other half will receive placebo.

Full description

Removable partial dentures are commonly constructed to replace missing teeth. It is observed that removable partial denture wearers are susceptible to dental caries.

The mode of action of silver diamine fluoride on caries prevention is dual: fluoride ions interact synergistically with silver to react with hydroxyapatite to form fluorapatite, and silver is bactericidal by reacting with the thiol groups of the amino and nucleic acids that halt the metabolic and reproductive functions of the cariogenic bacteria.

Enrollment: 196 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who are wearing removable partial dentures constructed by staff or students at the Prince Philip Dental Hospital are recruited

Exclusion criteria

• If they have less than 4 teeth in any dental arch, have advanced periodontal disease in 2 or more sextants, have received therapeutic radiation of the head and neck region, have concurrent systemic illness that alters salivary flow, or have participated in a clinical trial within 6 months before the commencement of participation in this study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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196 participants in 2 patient groups, including a placebo group

Silver diamine fluoride

Experimental group

Description:

38% silver diamine fluoride solution (Saforide, Toyo Seiyaku Kasei Co. Ltd., Osaka, Japan) is professionally applied to exposed coronal and root surfaces of all teeth every 6 months for 36 months.

Treatment:

Drug: Silver Diamine Fluoride

Distilled water

Placebo Comparator group

Description:

Distilled water is professionally applied to exposed coronal and root surfaces of all teeth every 6 months for 36 months.

Treatment:

Drug: Distilled Water