Simple Once Daily Triple Regimen Including Tenofovir, Emtricitabine and Efavirenz in HIV-1 Infected Patients (ANRS 1207)

French National Agency for Research on AIDS and Viral Hepatitis

Status and phase

Completed

Phase 3

Conditions

HIV Infection

Treatments

Drug: Efavirenz (EFV)

Drug: Emtricitabine (FTC)

Drug: Tenofovir (TDF)

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT00158457

IMEA 025

ANRS 1207

Details and patient eligibility

About

In the context of Sub-saharian Africa, this trial evaluate one of the most simple treatment available for HIV-1 infected patients. The combination proposed is a triple antiretroviral therapy with only one intake of 3 pills per day. This combination has already been studied in the North countries.

Here in Senegal, the efficacy and the compliance to treatment will be evaluated after 24, 48 and 96 weeks of treatment.

Enrollment

40 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Documented infection with HIV-1 (ELISA- Western Blot)
Outpatient of masculine or feminine gender
In female patients any risk of pregnancy must be avoid: women at least 1 year past menopause or being confirmed sterile or having an effective contraceptive device
No previous treatment with antiretroviral therapy
CDC group C (except tuberculosis if CD4 count is over 350 /ml), CDC group B with CD4+ count under 350/ml and CDC group A with CD4 count under 200/ml.
Patient has provided informed written consent
Patient must agree not to take any concomitant medication throughout the duration of the study without first informing the investigator

Exclusion criteria

Deficiency of the patient rendering participation in the study or understanding of the information imparted difficult or even impossible
Patient participating in a different clinical study
Presence of serious or developing pathology
Severe liver failure (TP under 50% et bilirubinemia over 3 LSN)
Thrombocytopenia with platelet level under 50 000 cells /ml
Known severe renal pathology (creatinine clearance under 50 ml/min)
Clinical or biological problem corresponding to indications of grade over or equal 3 of WHO classification
Karnofsky under 70 percent
Opportunistic infections
Patients taking medications not recommended in the context of the protocol