Simple Surgical Glove Compression to Prevent Chemotherapy-Induced Peripheral Neuropathy

Jinsong Lu

Status: Not yet enrolling

Conditions: Breast Cancer; Chemotherapy Induced Peripheral Neuropathy (CIPN); Neoadjuvant Therapy

Treatments: Procedure: Simple Surgical Glove Compression Technique

Study type: Interventional

Funder types: Other

Identifiers

NCT07169864

LY2025-246-C

Details and patient eligibility

About

To evaluate the preventive efficacy of a simple surgical glove compression technique in reducing the incidence and severity of Chemotherapy Induced Peripheral Neuropathy among patients receiving chemotherapy.

Enrollment: 44 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age ≥ 18 years;
• Histologically confirmed primary invasive breast cancer;
• Planned to receive ≥ 8 weeks of weekly neoadjuvant chemotherapy (utidelone plus cisplatin);
• ECOG performance status: 0-1;

Exclusion criteria

• Distant metastasis;
• Presence of sensory or motor neurological disorders, or symptoms related to peripheral neuropathy with CTCAE grade ≥ 2, or currently receiving medication for peripheral neuropathy;
• Conditions affecting limb function;
• Known allergy to glove materials (e.g., latex)

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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44 participants in 1 patient group

Group with surgical glove compression applied to the dominant hand

Experimental group

Treatment:

Procedure: Simple Surgical Glove Compression Technique