Simultaneous Injection of Propofol and Rocuronium in Inducing General Anesthesia

Seoul National University

Status: Completed

Conditions: Anesthesia; Functional

Treatments: Drug: administration of propofol and rocuronium

Study type: Interventional

Funder types: Other

Identifiers

NCT03270696

JHSeo_MV

Details and patient eligibility

About

This study is conducted to evaluate the efficacy of simultaneous injection of propofol and rocuronium in inducing general anesthesia.

Enrollment: 114 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing elective surgery requiring endotracheal intubation
• ASA I, II, and III
• above 20 years

Exclusion criteria

• refuse to enroll
• patients with risk of aspirating gastric contents
• patients in whom NMBs are contraindicated
• patients with predictors of difficult mask ventilation

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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114 participants in 2 patient groups

simultaneous administration of propofol and rocuronium

Experimental group

Description:

In this group, the investigator will administrate propofol (2ml/kg) and rocuronium (0.6mg/kg) simultaneously, and start facemask ventilation after patient loss consciousness to induce general anesthesia. The investigator will measure the mean tidal volume (TV) applied during facemask ventilation for 1 minute.

Treatment:

Drug: administration of propofol and rocuronium

ordinal administration of propofol and rocuronium

Experimental group

Description:

In this group, the investigator will administrate propofol (2ml/kg) first, and follow injection of rocuronium (0.6mg/kg) after patient loss consciousness and confirming facemask ventilation. The investigator will measure the mean tidal volume (TV) applied during facemask ventilation for 1 minute.

Treatment:

Drug: administration of propofol and rocuronium