Simultaneous Integrated Boost Technique in Breast Cancer Radiotherapy

Medical University of Graz

Status: Withdrawn

Conditions: Radiotherapy Side Effect; Breast Cancer

Treatments: Radiation: Simultaneous integrated boost

Study type: Interventional

Funder types: Other

Identifiers

NCT04535895

1094/2020

Details and patient eligibility

About

Adjuvant radiotherapy after breast conserving surgery has been shown to improve both local control and overall survival. Dose escalation of the tumor bed by addition of a boost after whole breast radiotherapy reduces the risk of local recurrence in invasive breast cancer.

Simultaneous integrated boost (SIB) techniques have been shown to provide more conformal treatment plans than conventional sequential boost, in addition, SIB enables a reduction in the overall treatment time by 1 week compared to conventional boost techniques.

The proposed study is aimed at evaluating radiation-induced toxicity in patients treated with breast-conserving surgery in combination with radiotherapy using SIB technique.

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Invasive breast cancer or ductal carcinoma in situ
• Breast conserving surgery
• Complete tumor resection
• Treatment with adjuvant radiotherapy of the breast
• Indication for boost Irradiation
• Given informed consent

Exclusion criteria

• Incomplete tumor resection
• Mastectomy
• Distant metastases at diagnosis
• Unable to give informed consent

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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0 participants in 1 patient group

Simultaneous integrated boost arm

Experimental group

Treatment:

Radiation: Simultaneous integrated boost