Simultaneously PET/MRI in Prolonged DOC Patients

Hangzhou Normal University

Status: Completed

Conditions: Minimally Conscious State; Disorder of Consciousness; Rs-fMRI; FDG-PET

Treatments: Diagnostic Test: Multimodal Neuroimaging

Study type: Observational

Funder types: Other

Identifiers

NCT04164680

2019N55749

Details and patient eligibility

About

Recently introduced hybrid PET/MR scanners provide the opportunity to measure simultaneously, and in direct spatial correspondence, both metabolic demand and functional activity of the brain, hence capturing complementary information on the brain's physiological state. Here we exploited PET/MR simultaneous imaging to explore the relationship between the metabolic information provided by resting-state fluorodeoxyglucose-PET (FDG-PET) and fMRI (rs-fMRI) in patients with disorders of consciousness.

Enrollment: 24 patients

Sex: All

Ages: 16 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• DOC patients （acute, subacute or chronic period）: Coma, UWS and MCS.

Exclusion criteria

• neuromuscular blocking agents or sedative drugs administered within the prior 24 hours；
• unstable medical condition；
• mental implant in the brain

Trial design

24 participants in 1 patient group

Patients with disorders of consciousness

Treatment:

Diagnostic Test: Multimodal Neuroimaging