Simvastatin Effect on End Stage Renal Failure Patients Treated by Peritoneal Dialysis

Federal University of São Paulo

Status and phase: Unknown; Phase 4

Conditions: Peritoneal Dialysis; Renal Failure, End Stage

Treatments: Drug: Simvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT00291863

0089/04

Details and patient eligibility

About

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

Full description

This study will analyse the effect of simvastatin on endothelium dependent venodilation in chronic renal failure patients treated by peritoneal dialysis. The hypothesis is that patients will have a greater endothelium dependent venodilation after four months of simvastatin use.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• end stage renal failure
• peritoneal dialysis
• LDL cholesterol > 100mg/dL
• > 18 years and < 80 years

Exclusion criteria

• using statin or nitrate
• liver disease
• diabetes mellitus

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind