Simvatstatin Used to Treat Pulmonary Hypertension

Capital Medical University

Status and phase: Unknown; Phase 1

Conditions: Hypertension, Pulmonary

Treatments: Drug: simvastatin

Study type: Interventional

Funder types: Other

Identifiers

NCT00538044

Anzhen1

Gan1

Details and patient eligibility

About

we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Full description

advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Sex: All

Ages: 12 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• pasp>50mmHg

Exclusion criteria

• pasp<50mmhg

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

1simvastatin group

Experimental group

Description:

before the operation, the patient start the simvastatin medication on the dosage of 40mg per day

Treatment:

Drug: simvastatin

2contral group

No Intervention group

Description:

just do routin operation with no use of simvastatin, other medication is exact the same as the simvastatin group