Single Blinded First CMC Osteoarthritis Treatment

Kettering Health Network

Status: Enrolling

Conditions: Osteoarthritis Thumb

Treatments: Drug: Corticosteroid injection; Other: Normal Saline; Drug: Platelet Concentrate

Study type: Interventional

Funder types: Other

Identifiers

NCT03196310

17-008

Details and patient eligibility

About

Single blinded PRP vs. Corticosteroid vs. Placebo (normal saline) intra-articular injection for basal joint arthritis.

Enrollment: 150 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Stage 1-3 osteoarthritis of the basal joint

Exclusion criteria

• Patients with Stage 4 1st carpometacarpal joint arthritis as described by Eaton
• Patients who have received a corticosteroid injection in the last year to the 1st CMC joint on the proposed study side
• Patients who have scaphotriquetral, radioscaphoid, or scaphotrapezial osteoarthritis
• Patients who have concurrent DeQuervain's tenosynovitis or intersection syndrome or have been treated for either of these in the last 3 months
• Patients undergoing evaluation of cervical radiculopathy
• Patients with fibromyalgia or inflammatory rheumatic disease
• Patients with Pressier disease, Kienbock's, or avascular necrosis of the scaphoid
• Patients with any history of primary or secondary bone tumor
• Patients that are pregnant or terminally ill

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 3 patient groups, including a placebo group

PRP

Experimental group

Description:

Intra-articular injection of platelet rich plasma.

Treatment:

Drug: Platelet Concentrate

Corticosteroid

Active Comparator group

Description:

Intra-articular injection of kenalog.

Treatment:

Drug: Corticosteroid injection

Normal Saline

Placebo Comparator group

Description:

Intra-articular injection of normal saline

Treatment:

Other: Normal Saline