Single-cell Landscape of BALF in Patients With Severe ARDS and CARDS

Chinese Academy of Medical Sciences & Peking Union Medical College

Status: Completed

Conditions: ARDS: Acute Respiratory Distress Syndrome; Covid19

Treatments: Drug: steroid

Study type: Observational

Funder types: Other

Identifiers

NCT05933291

Covid20230601

Details and patient eligibility

About

The goal of this observational study is to learn about the effect of steroid therapy in patients with COVID-19 ARDS. The main questions it aims to answer are:

• Differences between patients with COVID-19 ARDS before and after steroid treatment in BALF single cell landscape, as well as patients with different prognosis.
• Differences between COVID-19 and non COVID-19 ARDS patients in BALF single cell landscape.

Participants will Choose whether to use or not to utilize steroid treatment based on conditions.

Full description

Collect BALF from COVID-19 and non-COVID-19 ARDS patients both before and during remission, then perform single-cell sequencing.

Enrollment: 8 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Severe ARDS patients

Exclusion criteria

• None

Trial design

8 participants in 4 patient groups

COVID-19 with steroid

Description:

COVID-19 ARDS patients with steroid treatment

Treatment:

Drug: steroid

COVID-19 without steroid

Description:

COVID-19 ARDS patients without steroid treatment

non-COVID-19 with steroid

Description:

non-COVID-19 ARDS patients with steroid treatment

Treatment:

Drug: steroid

non-COVID-19 without steroid

Description:

non-COVID-19 ARDS patients without steroid treatment