Single Cell Sequencing Analysis of Thymoma

University of Chinese Academy Sciences

Status

Enrolling

Conditions

Thymoma

Treatments

Diagnostic Test: Tissue

Study type

Observational

Funder types

Other

Identifiers

NCT04162691

SCS-001

Details and patient eligibility

About

The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.

Enrollment

10 estimated patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients diagnosed with thymoma
Ability to provide written consent and comply with the protocol
At least 18 years of age

Exclusion criteria

Patients undergoing thymoma treatment
Patients with previous malignancy
Known HIV positive status.
Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.