Single-center Prospective Study of Non-invasive Methods for the Diagnosis of Postoperative Complications in Liver Transplant Recipients (ElastOLT)

Institute of Hospitalization and Scientific Care (IRCCS)

Status: Enrolling

Conditions: Rejection Acute Hepatic; Transplant; Failure, Liver; Liver Dysfunction

Study type: Observational

Funder types: Other

Identifiers

NCT05793203

4176

Details and patient eligibility

About

A lot of different early and late complications may occur after liver transplantation. They could be related to surgical procedure, to infectious diseases or immuno-mediated diseases (acute cellular rejection, ACR). Almost all of those complications are characterized by an elevation in liver enzymes (ALT, AST and GGT) and a decline of liver function tests (serum bilirubin and INR increase) possibly leading to early allograft disfunction (EAD). In this scenario there is a lack of biomarker that could predict the development of ACR and/or EAD.

The aim of this study is to explore the prognostic role of non-invasive instrumental and biological marker in the early post-transplant phase.

Enrollment: 100 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients eligible for liver transplantation following National and International Guidelines

Exclusion criteria

• No agreement or inability to give informed consent

  • Re-transplant patients
  • Liver transplant in fulminant hepatitis