Single Dose Cefepime Versus Cefuroxime Plus Metronidazole as a Prophylactic Antibiotic During Emergency Intrapartum Cesarean Section

Assiut University

Status and phase: Unknown; Phase 3; Phase 2

Conditions: Infection Wound; Emergency Cesarean Section

Treatments: Drug: Cefuroxime plus Metronidazole; Drug: Cefepime

Study type: Interventional

Funder types: Other

Identifiers

NCT04009772

Antibiotic CS

Details and patient eligibility

About

Compare between cefepime versus routine antibiotics as a prophylactic antibiotic during emergency cesarean section in a tertiary center of obstetric care

Full description

This is a randomized double blinded study which compare between single dose cefepime versus cefuroxime plus metronidazole during emergency intrapartum cesarean section.

Outcomes will include fever, wound infection, and urinary tract infection.

Enrollment: 500 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• intrapartum caesarean section

Exclusion criteria

• evidence of infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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500 participants in 2 patient groups

"Cefepime" , "Maxipime®" 1 gm

Active Comparator group

Description:

Patient will receive "Cefepime" ,"Maxipime®" 1 gm IV during cesarean section just before skin incision

Treatment:

Drug: Cefepime

"Cefuroxime", "Zinnat®" 1gm plus "metronidazole"Flagyl®" 500

Active Comparator group

Description:

Patient will receive "Cefuroxime", "Zinnat®" 1gm ,and "metronidazole"Flagyl®" 500 IV; just before skin incision for emergency cesarean section

Treatment:

Drug: Cefuroxime plus Metronidazole