Single Dose of Etomidate and Adrenal Cortex

Istanbul University

Status and phase: Completed; Phase 4

Conditions: Hemodynamic Instability; Adrenocortical Deficiency

Treatments: Drug: Etomidate; Drug: methylprednisolone; Drug: Midazolam

Study type: Interventional

Funder types: Other

Identifiers

NCT01792037

26177

Details and patient eligibility

About

we aim to evaluate the effects of single dose of etomidate or use of steroid prior to etomidate during emergency intubation on hemodynamics and adrenal cortex.

Enrollment: 90 patients

Sex: All

Ages: 25 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients between 25-65 years old with American Society of Anesthesiology scores III or IV that have applied to emergency department and receives an indication for intubation by the intensive care unit physicians will be included to the study

Exclusion criteria

• Patients using steroid prior to the intubation and/or patients with chronical inflammatory diseases will be excluded from the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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90 participants in 3 patient groups

Etomidate

Active Comparator group

Description:

After taking of the blood samples, patients in Group I will be intubated with 0.3 mg/kg etomidate iv. Blood samples will be repeated in the 4th and 24th hour of the intubation.systolic, diastolic and mean arterial pressures, heart rates will be recorded with 15 minutes intervals in the first hour and after that hourly during surgery.Cortisol Levels in the 0,4th and 24th hour will be compared from the blood samples acquired.

Treatment:

Drug: Etomidate

etomidate, steroid

Active Comparator group

Description:

After taking of the blood samples, patients in Group II will be intubated with 0.3 mg/kg etomidate iv following a 2mg/kg methylprednisolone iv Blood samples will be repeated in the 4th and 24th hour of the intubation.systolic, diastolic and mean arterial pressures, heart rates will be recorded with 15 minutes intervals in the first hour and after that hourly during surgery.Cortisol Levels in the 0,4th and 24th hour will be compared from the blood samples acquired.

Treatment:

Drug: methylprednisolone

Drug: Etomidate

midazolam

Active Comparator group

Description:

After taking of the blood samples, patients in Group III will be intubated with 0.01 mg/kg midazolam iv. Blood samples will be repeated in the 4th and 24th hour of the intubation.systolic, diastolic and mean arterial pressures, heart rates will be recorded with 15 minutes intervals in the first hour and after that hourly during surgery. Cortisol Levels in the 0,4th and 24th hour will be compared from the blood samples acquired.

Treatment:

Drug: Midazolam