Single Embryo TrAnsfeR of Euploid Embryo (STAR)

Illumina

Status

Completed

Conditions

Aneuploidy

Infertility

Treatments

Other: Preimplantation Genetic Screening by NGS

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT02268786

RGH-001

Details and patient eligibility

About

The purpose of the current study is to evaluate the effect of preimplantation genetic screening (PGS) by next generation sequencing (NGS) compared to standard morphological assessment of embryos on pregnancy rates through a randomized controlled trial (RCT). All embryos will be vitrified and a single embryo transfer (SET) will be performed with either screened or unscreened embryos depending on randomization.

Enrollment

661 patients

Sex

Female

Ages

25 to 40 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patient undergoing IVF
At least 2 blastocysts suitable for biopsy on day 5 or 6 of embryo development

Exclusion criteria

History of more than two prior implantation failure following IVF
History of more than one miscarriage of viable pregnancy
One or both partners known to be carrier(s) of a chromosomal abnormality
Known genetic carrier couple and/or one or both partners carrier of a known autosomal dominant disorder
Any other non-study related preimplantation genetic testing
Use of donor oocytes
Use of gestational carrier (surrogate or donor egg recipient).
Severe oligospermia (<1,000,000 sperm/ml); Surgical Sperm Retrieval for reasons other than post-vasectomy and CAVD
Low ovarian reserve with (FSH) >10 IU/L on day 2-4 of a prior menstrual cycle and/or (AMH) <7 pmol/L (or <1 ng/ml)
Gender selection cycles
Concurrent participation in another clinical trial