Single Gene Polymorphisms Associated With Molar-Incisor Hypomineralization

Marmara University

Status

Not yet enrolling

Conditions

Molar-Incisor Hypomineralization

Treatments

Diagnostic Test: DNA Sample Collection + DNA genotyping

Study type

Observational

Funder types

Other

Identifiers

NCT06165055

MarmaraPedo2

Details and patient eligibility

About

The genetic factors associated with Molar-Incisor Hypomineralization (MIH), a dental condition affecting permanent molars in individuals aged 8-13. Buccal swab samples collected from 90 MIH-affected participants and 90 systemically healthy controls. The goal is to identify potential genetic markers contributing to the etiology of MIH, shedding light on previously unexplored aspects of genetic susceptibility.

Full description

The aim of study is to elucidate the unknown aspects of genetic predisposition that may be effective in the etiology of Molar-Incisor Hypomineralization (MIH), that is, to identify unexplored genes that may be associated with MIH. The buccal swab method will be used for the purpose of collecting DNA samples.Samples will be collected from the inner cheek using a swab. The collected samples will be placed in single-use sterile Eppendorf tubes containing Phosphate Buffered Saline (PBS) solution. The samples will be stored at +4 degrees Celsius in a refrigerator, and DNA isolations will be performed within a few days. .

Enrollment

120 estimated patients

Sex

All

Ages

8 to 13 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients aged between 8 and 13 years
Patients whose parents consent to participate in the study
Patients who provide cooperation for treatment and study
For the study group: patients with at least one molar tooth showing molar-incisor hypomineralization
For the control group: patients without molar-incisor hypomineralization
Patients without a genetic disease in themselves or their family

Exclusion criteria