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Single Injection of Faricimab for nAMD With Persisting Fluid Despite Frequent Aflibercept Treatments

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Rigshospitalet

Status

Completed

Conditions

Neovascular Age-related Macular Degeneration

Treatments

Drug: Faricimab

Study type

Observational

Funder types

Other

Identifiers

NCT06124677
VAB1SHOT

Details and patient eligibility

About

The goal of this retrospective single-center chat review is to establish the efficacy and safety of a single dose of intravitreal faricimab (Vabysmo®) injection in patients with neovascular age-related macular degeneration (AMD), who were previously treated with aflibercept (Eylea®) and had persisting intraretinal or subretinal fluid despite frequent treatments.

Enrollment

46 patients

Sex

All

Ages

50+ years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion criteria

  • Presence of neovascular age-related macular degeneration (AMD) in the study eye
  • >50 years of age
  • Previous intravitreal anti-VEGF treatment with aflibercept (Eylea®) or with aflibercept and ranibizumab (Lucentis®) in the study eye
  • Minimum of 6 monthly aflibercept injections
  • Persisting intraretinal or subretinal fluid or both, despite at least 3 consecutive monthly aflibercept injections in the study eye before switching to faricimab

Exclusion criteria

  • Neovascular conditions other than AMD (e.g., choroidal neovascularisation due to other causes) or co-existence of other retinal disease in the study eye
  • Significant optical media opacities that would result in poor imaging quality on OCT scans in the study eye
  • Intraocular surgery in the study eye 3 months before or within 1 month after the treatment switch

Trial design

46 participants in 1 patient group

Patients
Description:
Patients who received intravitreal faricimab injections between May and September, in 2023. and conform the inclusion/exclusion criteria.
Treatment:
Drug: Faricimab

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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