Single Neurons Responses During Visual Recognition in Epileptic Patients (REUNIE)

Central Hospital, Nancy, France

Status: Unknown

Conditions: Epilepsy

Treatments: Behavioral: Face individualization; Procedure: Implantation of mixed intracerebral electrodes; Behavioral: Face detection

Study type: Interventional

Funder types: Other

Identifiers

NCT02877576

2015-A01951-48

Details and patient eligibility

About

The purpose is to evaluate specific capacities of face detection of individual neurons by comparison with their capacity of object detection in medial temporal lobe and ventral temporal cortex in epileptic patients.

Secondary purpose is to evaluate specific capacities of detection of known faces of individual neurons by comparison with their capacity of detection of unknown faces in medial temporal lobe and ventral temporal cortex in epileptic patients.

Full description

In this interventional study, patients explored with mixed intracerebral electrodes (micro and macro-contacts) will be presented sets of images (objects, unknown faces, famous faces). Spikes and Multi-Unit-Activity will be recorded and analyzed and compared between conditions.

Enrollment: 20 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patient with temporal or occipito-temporal drug-resistant partial epilepsy, symptomatic, needing surgical treatment
• Patient having signed informed consent
• Patient affiliated to social security
• Patient having undergone preliminary medical examination

Exclusion criteria

• Persons under legal protection or incapable to consent
• Persons deprived of liberty by juridical or administrative decision
• Patient with severe visual disorders of neurological or ophthalmological origin
• Patients with infection risk according to doctor or surgeon
• Women without effective contraception
• Pregnant or breast-feeding women

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Epileptic patient

Experimental group

Description:

micro-electrode recordings interventions: Implantation of mixed intracerebral electrodes Face detection Face individualization

Treatment:

Procedure: Implantation of mixed intracerebral electrodes

Behavioral: Face individualization

Behavioral: Face detection