Single Nucleotide Polymorphisms (SNPs) Associated With Postherpetic Neuralgia

Zhejiang University

Status: Completed

Conditions: Postherpetic Neuralgia

Study type: Observational

Funder types: Other

Identifiers

NCT03708653

2018-0904

Details and patient eligibility

About

Postherpetic neuralgia (PHN) is a common condition and affecting 5 to 30% of the herpes zoster patients. In some cases, the pain remained refractory after first and second line treatment for herpes zoster. This suggests that there may be genetic variants that make some patients susceptible to PHN. Using saliva samples from herpes zoster patients the investigators are going to analyze the relationship between single nucleotide polymorphisms (SNPs) in genes that are known to be involved in pain and PHN.

Enrollment: 181 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age more than 50 years
• Clinically defined herpes zoster patients

Exclusion criteria

• Patients not able to provide informed consent

Trial design

181 participants in 2 patient groups

PHN(+)

Description:

Patients who have persistent pain more than three months after the onset of herpes zoster.

PHN(-)

Description:

Patients whose pain disappear within three months.