Single Photon Emission Computed Tomography (SPECT) Lymph Node Mapping

The Washington University

Status: Completed

Conditions: Adenocarcinoma of the Prostate

Treatments: Other: Single Photon Emission Computed Tomography (SPECT)

Study type: Interventional

Funder types: Other

Identifiers

NCT00608920

06-0772

Details and patient eligibility

About

The purpose of this study is to determine if the planning of radiation treatment of prostate cancer patient can be made more precise by comparing currently planning techniques to an imaging technique called SPECT.

Full description

Single photon emission computed tomography (SPECT) uses radioactive tracers and a scanner to record data that a computer constructs into two- or three-dimensional images. A small amount of a radioactive drug is injected into the body and a scanner is used to make detailed images of areas inside the body where the radioactive material is taken up by the cells. Using a gamma camera (a special kind of scanner), we can create a better picture of the lymph node region. We will compare these pictures to images from your CT scan, to help plan your therapy.

The research in this study involves seeing if it is feasible to use SPECT scanning procedures for the purpose of planning your radiation treatment. We hope that doing so will allow us to more accurately and precisely plan radiation treatment to potential sites of cancer, and avoid delivering too much radiation to normal

Enrollment: 15 patients

Sex: Male

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with biopsy proven adenocarcinoma of the prostate
• Patients with at least one of the following high risk clinical features at the time of presentation:
• Extra-prostatic extension (on palpation or radiographic imaging)
• PSA ≥ 20
• Gleason Score ≥ 8
• Patients scheduled to receive prostatic and pelvic IMRT with ACCULOC® target localization
• Age > 18 years
• ECOG Performance Status ≤ 2
• Willing and able to sign informed consent document.-

Exclusion criteria

• History of radical prostatectomy
• History of prior pelvic radiation-

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

15 participants in 1 patient group

SPECT lymph node mapping

Experimental group

Description:

1. Diagnostic pelvic CT 2. Nuclear tracer injection (Tc-99m) - same time as the ACCULOC seed implantation 3. CT simulation (2 hours after prostate markers are placed) 4. SPECT lymphoscintigraphy (first set of images 3-6 hours after injection and second set may be obtained 18-24 hours after injection)

Treatment:

Other: Single Photon Emission Computed Tomography (SPECT)