Single Session Combined Locoregional Therapies for Hepatocellular Carcinoma

Sherief Abd-Elsalam

Status and phase: Unknown; Phase 3

Conditions: Liver Cancer

Treatments: Procedure: Microwave ablation combined with TACE; Procedure: Radiofrequency ablation combined with TACE; Drug: Transarterial chemoembolization (TACE)

Study type: Interventional

Funder types: Other

Identifiers

NCT02646137

Combined TACE and RF

Details and patient eligibility

About

Hepatocellular carcinoma is the third most common cause of cancer-related mortality. In recent years, transarterial chemoembolization, radio frequency ablation and microwave ablation have been accepted as treatment modalities for patients with surgically unresectable hepatocellular carcinoma.

Full description

To compare between combination treatment with radiofrequency or microwave ablation followed by transarterial chemoembolization and performed in a single session.

Enrollment: 50 estimated patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Child classification A or B.
• serum albumin ≥ 3 gm/L.
• serum bilirubin < 2.5 mg/dL.
• platelet count ≥70,000 mm3.
• INR ≤ 1.6.
• serum creatinine < 2 mg/dl.
• tumor size more than 4 cm and confined to one lobe of the liver.

Exclusion criteria

• Patients with portal vein thrombosis.
• A technically inaccessible hepatic artery.
• Metastatic HCC.
• More than three lesions.
• lesions in close proximity to the portal vein (PV),inferior vena cava (IVC) or gall bladder were excluded from the study.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

50 participants in 3 patient groups

Transarterial chemoembolization (TACE)

Active Comparator group

Description:

treated by transarterial chemoembolization

Treatment:

Drug: Transarterial chemoembolization (TACE)

Radiofrequency ablation with TACE

Experimental group

Description:

Radiofrequency ablation combined with TACE

Treatment:

Procedure: Radiofrequency ablation combined with TACE

Microwave ablation combined with TACE

Experimental group

Description:

Microwave ablation combined with TACE.

Treatment:

Procedure: Microwave ablation combined with TACE